The role of costimulatory molecules as targets for new immunosuppressives in transplantation
K Kishimoto, VM Dong, MH Sayegh - Current opinion in urology, 2000 - journals.lww.com
K Kishimoto, VM Dong, MH Sayegh
Current opinion in urology, 2000•journals.lww.comT-cell costimulation is critical for all T-cell-mediated immune responses that are responsible
for endpoints such as allograft rejection or autoimmune disease. Recent experimental data
elucidate specific pathways for T-cell activation and negative regulatory mechanisms via
unique costimulatory molecules. These data have implications for the development of novel
therapeutic strategies to prevent graft rejection and improve long-term graft survival in
transplant patients, and to treat autoimmune diseases in humans.
for endpoints such as allograft rejection or autoimmune disease. Recent experimental data
elucidate specific pathways for T-cell activation and negative regulatory mechanisms via
unique costimulatory molecules. These data have implications for the development of novel
therapeutic strategies to prevent graft rejection and improve long-term graft survival in
transplant patients, and to treat autoimmune diseases in humans.
Abstract
T-cell costimulation is critical for all T-cell-mediated immune responses that are responsible for endpoints such as allograft rejection or autoimmune disease. Recent experimental data elucidate specific pathways for T-cell activation and negative regulatory mechanisms via unique costimulatory molecules. These data have implications for the development of novel therapeutic strategies to prevent graft rejection and improve long-term graft survival in transplant patients, and to treat autoimmune diseases in humans.
Lippincott Williams & Wilkins