Induction of tolerance to an IgG autoantibody.
D Offen, L Spatz, H Escowitz… - Proceedings of the …, 1992 - National Acad Sciences
D Offen, L Spatz, H Escowitz, S Factor, B Diamond
Proceedings of the National Academy of Sciences, 1992•National Acad SciencesNonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA
antibody express the transgene in lymphoid organs and display partial allelic exclusion of
this gamma 2b transgene. The spleens of these mice are characterized by marked B-cell
depletion. Although there are B cells in these mice that express the transgene and recognize
double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in
vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the …
antibody express the transgene in lymphoid organs and display partial allelic exclusion of
this gamma 2b transgene. The spleens of these mice are characterized by marked B-cell
depletion. Although there are B cells in these mice that express the transgene and recognize
double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in
vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the …
Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this gamma 2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.
National Acad Sciences