[HTML][HTML] TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix
WH Yu, CY Shuan-su, Q Meng, K Brew… - Journal of Biological …, 2000 - ASBMB
Of the four known tissue inhibitors of metalloproteinases (TIMPs), TIMP-3 is distinguished by
its tighter binding to the extracellular matrix. The present results show that
glycosaminoglycans such as heparin, heparan sulfate, chondroitin sulfates A, B, and C, and
sulfated compounds such as suramin and pentosan efficiently extract TIMP-3 from the
postpartum rat uterus. Enzymatic treatment by heparinase III or chondroitinase ABC also
releases TIMP-3, but neither one alone gives complete release. Confocal microscopy shows …
its tighter binding to the extracellular matrix. The present results show that
glycosaminoglycans such as heparin, heparan sulfate, chondroitin sulfates A, B, and C, and
sulfated compounds such as suramin and pentosan efficiently extract TIMP-3 from the
postpartum rat uterus. Enzymatic treatment by heparinase III or chondroitinase ABC also
releases TIMP-3, but neither one alone gives complete release. Confocal microscopy shows …