[HTML][HTML] Mutations in the Heparin Binding Domain of Fibronectin in Cooperation with the V Region Induce Decreases in pp125FAKLevels Plus Proteoglycan-mediated …
YL Kapila, S Wang, PW Johnson - Journal of Biological Chemistry, 1999 - ASBMB
Intact fibronectin (FN) protects cells from apoptosis. When FN is fragmented, specific
domains induce proteinase expression in fibroblasts. However, it is not known whether
specific domains of FN can also regulate apoptosis. We exposed fibroblasts to four
recombinant FN fragments and then assayed for apoptosis using criteria of cellular shape
change, condensed nuclear morphology, and DNA fragmentation. The fragments extended
from the RGD-containing repeat III10 to III15; they included (V+) or excluded (V−) the …
domains induce proteinase expression in fibroblasts. However, it is not known whether
specific domains of FN can also regulate apoptosis. We exposed fibroblasts to four
recombinant FN fragments and then assayed for apoptosis using criteria of cellular shape
change, condensed nuclear morphology, and DNA fragmentation. The fragments extended
from the RGD-containing repeat III10 to III15; they included (V+) or excluded (V−) the …