INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS: Tissue Inhibitors of Matrix Metalloproteinases in Cancer
L Blavier, P Henriet, S Imren… - Annals of the New York …, 1999 - Wiley Online Library
L Blavier, P Henriet, S Imren, YA DeClerck
Annals of the New York Academy of Sciences, 1999•Wiley Online LibraryTissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis
of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases
(MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity,
which affects cell proliferation and survival. The role of these inhibitors in cancer has been
the subject of extensive investigations that have examined their biological activity in tumor
growth, invasion, metastasis and angiogenesis, as well as their potential use in the …
of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases
(MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity,
which affects cell proliferation and survival. The role of these inhibitors in cancer has been
the subject of extensive investigations that have examined their biological activity in tumor
growth, invasion, metastasis and angiogenesis, as well as their potential use in the …
Abstract
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival. The role of these inhibitors in cancer has been the subject of extensive investigations that have examined their biological activity in tumor growth, invasion, metastasis and angiogenesis, as well as their potential use in the diagnosis and treatment of human cancer.
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