Macrophage vitronectin receptor, CD36, and thrombospondin cooperate in recognition of neutrophils undergoing programmed cell death
J Savill, N Hogg, C Haslett - Chest, 1991 - journal.chestnet.org
Despite the injurious potential of neutrophil (PMN) contents, their fate at inflamed sites is
poorly under-stood. Although it is widely assumed that PMNs inevitably disintegrate before
their removal by local macropbages, an alternative fate has been described by which aging
PMNs, derived from blood or from inflamed sites, undergo apoptosis, which leads to
macrophage ingestion of the intact senescent PMN.• Macrophage recognition of apoptotic
PMNs occurs via a novel mechanism• that does not appear to stimulate the macrophage to …
poorly under-stood. Although it is widely assumed that PMNs inevitably disintegrate before
their removal by local macropbages, an alternative fate has been described by which aging
PMNs, derived from blood or from inflamed sites, undergo apoptosis, which leads to
macrophage ingestion of the intact senescent PMN.• Macrophage recognition of apoptotic
PMNs occurs via a novel mechanism• that does not appear to stimulate the macrophage to …