[HTML][HTML] Urokinase-type plasminogen activator stimulates the Ras/Extracellular Signal-regulated Kinase (ERK) signaling pathway and MCF-7 cell migration by a …
DHD Nguyen, DJ Webb, AD Catling, Q Song… - Journal of Biological …, 2000 - ASBMB
Urokinase-type plasminogen activator (uPA) stimulates MCF-7 cell migration by binding to
the UPA receptor and activating the Ras-extracellular signal-regulated kinase (Ras-ERK)
signaling pathway. Studies presented here show that soluble uPA receptor and a peptide
derived from the linker region between domains 1 and 2 of the uPA receptor also stimulate
cellular migration via a mitogen-activated protein kinase/ERK kinase (MEK)-dependent
pathway. Signaling proteins that function upstream of Ras in uPA-stimulated cells remain …
the UPA receptor and activating the Ras-extracellular signal-regulated kinase (Ras-ERK)
signaling pathway. Studies presented here show that soluble uPA receptor and a peptide
derived from the linker region between domains 1 and 2 of the uPA receptor also stimulate
cellular migration via a mitogen-activated protein kinase/ERK kinase (MEK)-dependent
pathway. Signaling proteins that function upstream of Ras in uPA-stimulated cells remain …