[HTML][HTML] The low density lipoprotein receptor-related protein/α2-macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast …
JC Zhang, R Sakthivel, D Kniss, CH Graham… - Journal of Biological …, 1998 - ASBMB
The low density lipoprotein receptor-related protein/α 2-macroglobulin receptor (LRP/α 2
MR) mediates the internalization of numerous ligands, including prourokinase (pro-UK) and
complexes between two-chain urokinase (tc-u-PA) and plasminogen activator inhibitor type-
1 (PAI-1). It has been suggested that through its ability to internalize these ligands, LRP/α 2
MR may regulate the expression of plasminogen activator activity on cell surfaces; this
hypothesis, however, has not been experimentally confirmed. To address this issue, we …
MR) mediates the internalization of numerous ligands, including prourokinase (pro-UK) and
complexes between two-chain urokinase (tc-u-PA) and plasminogen activator inhibitor type-
1 (PAI-1). It has been suggested that through its ability to internalize these ligands, LRP/α 2
MR may regulate the expression of plasminogen activator activity on cell surfaces; this
hypothesis, however, has not been experimentally confirmed. To address this issue, we …