[HTML][HTML] Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells
H Barnes, B Larsen, M Tyers, P van der Geer - Journal of Biological …, 2001 - ASBMB
v-Src transforms fibroblasts in vitroand causes tumor formation in the animal by tyrosine
phosphorylation of critical cellular substrates. Exactly how v-Src interacts with these
substrates remains unknown. One of its substrates, the adaptor protein Shc, is thought to
play a crucial role during cellular transformation by v-Src by linking v-Src to Ras. We used
Shc proteins with mutations in either the phosphotyrosine binding (PTB) or Src homology 2
domain to determine that phosphorylation of Shc in v-Src-expressing cells depends on the …
phosphorylation of critical cellular substrates. Exactly how v-Src interacts with these
substrates remains unknown. One of its substrates, the adaptor protein Shc, is thought to
play a crucial role during cellular transformation by v-Src by linking v-Src to Ras. We used
Shc proteins with mutations in either the phosphotyrosine binding (PTB) or Src homology 2
domain to determine that phosphorylation of Shc in v-Src-expressing cells depends on the …