TCR V gene usage in autoimmunity
DP Gold - Current opinion in immunology, 1994 - Elsevier
DP Gold
Current opinion in immunology, 1994•ElsevierWith the use of polymerase chain reaction technology, investigators now have the ability to
assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen
receptors expressed by pathogenic cells present in virtually any disease site. A summary of
studies of T cell receptor variable gene usage suggests that preferential expression can be
identified most reproducibly when cells are isolated directly from pathogenic lesions. This
provides a framework for future investigations in other autoimmune settings.
assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen
receptors expressed by pathogenic cells present in virtually any disease site. A summary of
studies of T cell receptor variable gene usage suggests that preferential expression can be
identified most reproducibly when cells are isolated directly from pathogenic lesions. This
provides a framework for future investigations in other autoimmune settings.
Abstract
With the use of polymerase chain reaction technology, investigators now have the ability to assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen receptors expressed by pathogenic cells present in virtually any disease site. A summary of studies of T cell receptor variable gene usage suggests that preferential expression can be identified most reproducibly when cells are isolated directly from pathogenic lesions. This provides a framework for future investigations in other autoimmune settings.
Elsevier