[HTML][HTML] Gi-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility …
T Ohmori, Y Yatomi, H Okamoto, Y Miura, G Rile… - Journal of Biological …, 2001 - ASBMB
Since blood platelets release sphingosine 1-phosphate (Sph-1-P) upon activation, it is
important to examine the effects of this bioactive lipid on vascular endothelial cell functions
from the viewpoint of platelet-endothelial cell interactions. In the present study, we examined
Sph-1-P-stimulated signaling pathways related to human umbilical vein endothelial cell
(HUVEC) motility, with a special emphasis on the cytoskeletal docking protein Crk-
associated substrate (Cas). Sph-1-P stimulated tyrosine phosphorylation of Cas, which was …
important to examine the effects of this bioactive lipid on vascular endothelial cell functions
from the viewpoint of platelet-endothelial cell interactions. In the present study, we examined
Sph-1-P-stimulated signaling pathways related to human umbilical vein endothelial cell
(HUVEC) motility, with a special emphasis on the cytoskeletal docking protein Crk-
associated substrate (Cas). Sph-1-P stimulated tyrosine phosphorylation of Cas, which was …