Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats
K Takeuchi, K Yagi, S Kato, H Ukawa - Gastroenterology, 1997 - gastrojournal.org
BACKGROUND & AIMS: Receptors activated by prostaglandin (PG) E2 are
pharmacologically subdivided into four subtypes (EP1-EP4). The EP-receptor subtype (s)
involved in stimulation of gastroduodenal HCO3-secretion in rats were investigated.
METHODS: Under urethane anesthesia, a stomach mounted in an ex vivo chamber or a
proximal duodenal loop was perfused with saline, and HCO3-secretion was measured using
a pH-stat method. RESULTS: Intravenous PGE2 increased HCO3-secretion by the …
pharmacologically subdivided into four subtypes (EP1-EP4). The EP-receptor subtype (s)
involved in stimulation of gastroduodenal HCO3-secretion in rats were investigated.
METHODS: Under urethane anesthesia, a stomach mounted in an ex vivo chamber or a
proximal duodenal loop was perfused with saline, and HCO3-secretion was measured using
a pH-stat method. RESULTS: Intravenous PGE2 increased HCO3-secretion by the …