[HTML][HTML] TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
S Abdollah, M Macı́as-Silva, T Tsukazaki… - Journal of Biological …, 1997 - ASBMB
Mothers against Dpp-related or Smad proteins are essential components of serine/threonine
kinase receptor signaling pathways that are regulated by phosphorylation. Recently, it was
demonstrated that Smad2 interacts transiently with and is a direct substrate of the
transforming growth factor-β (TGF-β) type I receptor, TβRI. Phosphorylation sites on Smad2
were localized to a carboxyl-terminal fragment containing three serine residues at positions
464, 465, and 467. In this report, we show that TβRI specifically phosphorylates Smad2 on …
kinase receptor signaling pathways that are regulated by phosphorylation. Recently, it was
demonstrated that Smad2 interacts transiently with and is a direct substrate of the
transforming growth factor-β (TGF-β) type I receptor, TβRI. Phosphorylation sites on Smad2
were localized to a carboxyl-terminal fragment containing three serine residues at positions
464, 465, and 467. In this report, we show that TβRI specifically phosphorylates Smad2 on …