The genesis of immune privilege high in the evolutionary tree suggests that immune
privilege is necessary, if not advantageous for the progressive development of the CNS.
Upon reaching a certain degree of complexity, it seems as if the CNS was obliged to restrain
the immune system from penetrating the blood–brain barrier. CNS autoimmunity against
myelin proteins is known to be a contributory factor in the pathophysiology of multiple
sclerosis and in the animal model of experimental autoimmune encephalomyelitis …