Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
M Laschinger, B Engelhardt - Journal of neuroimmunology, 2000 - Elsevier
Based on the observation that antibodies directed against α4-integrin and its
counterreceptor VCAM-1 inhibit inflammatory cell recruitment into the central nervous
system (CNS) during experimental autoimmune encephalomyelitis (EAE), it has been
concluded that α4-integrin/VCAM-1 interaction plays a critical role in T cell interaction with
the blood–brain barrier (BBB) endothelium. In order to define the exact role of α4-integrin
and VCAM-1 in T cell recruitment across the BBB endothelium we set up in vitro studies …
counterreceptor VCAM-1 inhibit inflammatory cell recruitment into the central nervous
system (CNS) during experimental autoimmune encephalomyelitis (EAE), it has been
concluded that α4-integrin/VCAM-1 interaction plays a critical role in T cell interaction with
the blood–brain barrier (BBB) endothelium. In order to define the exact role of α4-integrin
and VCAM-1 in T cell recruitment across the BBB endothelium we set up in vitro studies …