Distinct roles for matrix metalloproteinase-2 and α4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune …
D Graesser, S Mahooti, JA Madri - Journal of neuroimmunology, 2000 - Elsevier
Expression of α4 integrin by auto-reactive T cells is critical for their ability to induce EAE, an
autoimmune disease of the central nervous system in mice, used as a model to study human
multiple sclerosis. Having previously identified one role for α4 integrin in adhesion-mediated
induction of matrix metalloproteinase-2 (MMP-2), an enzyme that degrades the
subendothelial basement membrane matrix, we investigated independent roles for MMP-2
and α4 integrin during EAE. The data suggest that expression of α4 integrin by auto-reactive …
autoimmune disease of the central nervous system in mice, used as a model to study human
multiple sclerosis. Having previously identified one role for α4 integrin in adhesion-mediated
induction of matrix metalloproteinase-2 (MMP-2), an enzyme that degrades the
subendothelial basement membrane matrix, we investigated independent roles for MMP-2
and α4 integrin during EAE. The data suggest that expression of α4 integrin by auto-reactive …