[HTML][HTML] Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes (∗)
D Guo, DB Donner - Journal of Biological Chemistry, 1996 - ASBMB
Chronic incubation of 3T3-L1 adipocytes with tumor necrosis factor (TNF) induces a state of
insulin resistance characterized by a diminished ability of insulin to induce phosphorylation
of the β subunit of its own receptor and insulin receptor substrate 1 (IRS-1). When
adipocytes are briefly pretreated with TNF and then stimulated with insulin, tyrosine
phosphorylation of IRS-1 increases above the level induced by insulin alone. By itself, TNF
induces the time-dependent tyrosine phosphorylation of proteins in 3T3-L1 adipocytes …
insulin resistance characterized by a diminished ability of insulin to induce phosphorylation
of the β subunit of its own receptor and insulin receptor substrate 1 (IRS-1). When
adipocytes are briefly pretreated with TNF and then stimulated with insulin, tyrosine
phosphorylation of IRS-1 increases above the level induced by insulin alone. By itself, TNF
induces the time-dependent tyrosine phosphorylation of proteins in 3T3-L1 adipocytes …