Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases

PJ Barnes, M Karin - New England journal of medicine, 1997 - Mass Medical Soc
New England journal of medicine, 1997Mass Medical Soc
In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel
disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to
the site of lesions, thereby amplifying and perpetuating the inflammatory state. 1 These
activated cells produce many other mediators of inflammation. What causes these diseases
is still a mystery, but the disease process results from an interplay of genetic and
environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in …
In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.1 These activated cells produce many other mediators of inflammation.
What causes these diseases is still a mystery, but the disease process results from an interplay of genetic and environmental factors. Genes, such as those for atopy in asthma and for HLA antigens in rheumatoid arthritis and inflammatory bowel disease, may determine a patient's susceptibility to the disease and the disease's severity, but environmental factors, often unknown, . . .
The New England Journal Of Medicine