[HTML][HTML] Fibroblast growth factor-2 stimulation of p42/44MAPKphosphorylation and IκB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts
M Delehedde, M Seve, N Sergeant, I Wartelle… - Journal of Biological …, 2000 - ASBMB
Fibroblast growth factor-2 (FGF-2) interacts with a dual receptor system consisting of tyrosine
kinase receptors and heparan sulfate proteoglycans (HSPGs). In rat mammary fibroblasts,
FGF-2 stimulated DNA synthesis and induced a sustained phosphorylation of p42/44 MAPK
and of its downstream target, p90 RSK. Moreover, FGF-2 also stimulated the transient
degradation of IκBα and IκBβ. PD098059, a specific inhibitor of p42/44 MAPK
phosphorylation, inhibited FGF-2-stimulated DNA synthesis, phosphorylation of p42/44 …
kinase receptors and heparan sulfate proteoglycans (HSPGs). In rat mammary fibroblasts,
FGF-2 stimulated DNA synthesis and induced a sustained phosphorylation of p42/44 MAPK
and of its downstream target, p90 RSK. Moreover, FGF-2 also stimulated the transient
degradation of IκBα and IκBβ. PD098059, a specific inhibitor of p42/44 MAPK
phosphorylation, inhibited FGF-2-stimulated DNA synthesis, phosphorylation of p42/44 …