Development and selection of T cells: facts and puzzles
P Kisielow, H Von Boehmer - Advances in immunology, 1995 - Elsevier
Mature T cells are essential components of the immune system. They represent
phenotypically and functionally heterogenous populations of lymphocytes that are equipped
with unique, clonally distributed, heterodimeric (α/β or γδ) T cell receptors (TCR), which
unlike antigen-specific immunoglobulin (Ig) receptors on B cells, are designed to recognize
exclusively cell-bound antigens and cannot be blocked by free antigen.To cope with various
kinds of subversive agents exhibiting different biological properties, several lineages of T …
phenotypically and functionally heterogenous populations of lymphocytes that are equipped
with unique, clonally distributed, heterodimeric (α/β or γδ) T cell receptors (TCR), which
unlike antigen-specific immunoglobulin (Ig) receptors on B cells, are designed to recognize
exclusively cell-bound antigens and cannot be blocked by free antigen.To cope with various
kinds of subversive agents exhibiting different biological properties, several lineages of T …