[HTML][HTML] Crystal Structure of the Sulfotransferase Domain of Human Heparan SulfateN-Deacetylase/N-Sulfotransferase 1
Y Kakuta, T Sueyoshi, M Negishi… - Journal of Biological …, 1999 - ASBMB
Heparan sulfateN-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory
step in the biosynthesis of heparan sulfates and heparin. The crystal structure of the
sulfotransferase domain (NST1) of human HSNST-1 has been determined at 2.3-Å
resolution in a binary complex with 3′-phosphoadenosine 5′-phosphate (PAP). NST1 is
approximately spherical with an open cleft, and consists of a single α/β fold with a central
five-stranded parallel β-sheet and a three-stranded anti-parallel β-sheet bearing an …
step in the biosynthesis of heparan sulfates and heparin. The crystal structure of the
sulfotransferase domain (NST1) of human HSNST-1 has been determined at 2.3-Å
resolution in a binary complex with 3′-phosphoadenosine 5′-phosphate (PAP). NST1 is
approximately spherical with an open cleft, and consists of a single α/β fold with a central
five-stranded parallel β-sheet and a three-stranded anti-parallel β-sheet bearing an …