[HTML][HTML] Regulated diversity of heparan sulfate

U Lindahl, M Kusche-Gullberg, L Kjellén - Journal of Biological Chemistry, 1998 - ASBMB
Large numbers of proteins in animal tissues occur immobilized in the extracellular space, at
cell surfaces or in the extracellular matrix. Some are anchored through interactions with
other proteins. However, current research increasingly implicates proteoglycans as scaffold
structures, designed to accommodate proteins through noncovalent binding to their
glycosaminoglycan side chains (1). In particular, heparan sulfate (HS) 1 proteoglycans are
recognized as ubiquitous protein ligands. Binding of proteins to HS chains may serve a …