[HTML][HTML] Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress …
N Reunanen, J Westermarck, L Häkkinen… - Journal of Biological …, 1998 - ASBMB
Inflammatory cytokines tumor necrosis factor-α and interleukin-1 trigger the ceramide
signaling pathway, initiated by neutral sphingomyelinase-elicited hydrolysis of cell
membrane phospholipid sphingomyelin to ceramide, a new lipid second messenger. Here,
we show that triggering the ceramide pathway by sphingomyelinase or C 2-and C 6-
ceramide enhances collagenase-1 (matrix metalloproteinase-1; MMP-1) gene expression by
fibroblasts. C 2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) …
signaling pathway, initiated by neutral sphingomyelinase-elicited hydrolysis of cell
membrane phospholipid sphingomyelin to ceramide, a new lipid second messenger. Here,
we show that triggering the ceramide pathway by sphingomyelinase or C 2-and C 6-
ceramide enhances collagenase-1 (matrix metalloproteinase-1; MMP-1) gene expression by
fibroblasts. C 2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) …