[HTML][HTML] Essential role of human leukocyte antigen-encoded proteasome subunits in NF-κB activation and prevention of tumor necrosis factor-α-induced apoptosis
T Hayashi, D Faustman - Journal of Biological Chemistry, 2000 - ASBMB
The multisubunit proteasome complex is the principal mediator of nonlysosomal protein
degradation. The proteasome subunit varies minimally between cells with the exception of
LMP2, LMP7, and LMP10 subunits in rodent and human cells. LMP2 and LMP7 subunits are
encoded by the human lymphocyte antigen region, and they optimize proteolytic mediated
antigen presentation. The proteasome is also important for the function of transcription factor
nuclear factor-κB (NF-κB). It is required for NF-κB subunits p50 and p52 generation and …
degradation. The proteasome subunit varies minimally between cells with the exception of
LMP2, LMP7, and LMP10 subunits in rodent and human cells. LMP2 and LMP7 subunits are
encoded by the human lymphocyte antigen region, and they optimize proteolytic mediated
antigen presentation. The proteasome is also important for the function of transcription factor
nuclear factor-κB (NF-κB). It is required for NF-κB subunits p50 and p52 generation and …