Prostaglandin E2 inhibits B lymphocyte activation by a cAMP-dependent mechanism: PGE-inducible regulatory proteins
RL Roper, JW Ludlow, RP Phipps - Cellular immunology, 1994 - Elsevier
We have previously shown that macrophage-secreted prostaglandins of the E series (PGE)
and other agents which increase cAMP inhibit IgM production and proliferation of murine B
lymphocytes. In this study, we show that PGE 2 inhibits B cell activation events including
enlargement, class II MHC hyperexpression, and the expression of the low-affinity receptor
for IgE, FcϵRII/CD23 (35-50%) in a cAMP-dependent manner. PGE action is mimicked by
other cAMP-inducing agents and is inhibited by RpcAMP (a nonhydrolyzable cAMP analog …
and other agents which increase cAMP inhibit IgM production and proliferation of murine B
lymphocytes. In this study, we show that PGE 2 inhibits B cell activation events including
enlargement, class II MHC hyperexpression, and the expression of the low-affinity receptor
for IgE, FcϵRII/CD23 (35-50%) in a cAMP-dependent manner. PGE action is mimicked by
other cAMP-inducing agents and is inhibited by RpcAMP (a nonhydrolyzable cAMP analog …