[HTML][HTML] The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region
K De Vos, V Goossens, E Boone, D Vercammen… - Journal of Biological …, 1998 - ASBMB
The cytokine tumor necrosis factor (TNF) activates diverse signaling molecules resulting in
gene expression, differentiation, and/or cell death. Here we report a novel feature induced
by TNF, namely translocation of mitochondria from a dispersed distribution to a perinuclear
cluster. Mitochondrial translocation correlated with sensitivity to the cell death-inducing
activity of TNF and was mediated by the 55-kDa TNF receptor (TNF-R55), but not by Fas,
indicating that the signaling pathway requires a TNF-R55-specific but death domain …
gene expression, differentiation, and/or cell death. Here we report a novel feature induced
by TNF, namely translocation of mitochondria from a dispersed distribution to a perinuclear
cluster. Mitochondrial translocation correlated with sensitivity to the cell death-inducing
activity of TNF and was mediated by the 55-kDa TNF receptor (TNF-R55), but not by Fas,
indicating that the signaling pathway requires a TNF-R55-specific but death domain …