Tumor necrosis factor-α (TNF-α) binding to its receptors leads to a diversity of biological
responses. The actions of TNF are the result of the interaction of cytoplasmic proteins that
bind directly to the intracellular domains of the two TNF receptors, p55 and p75. Here we
report a novel interaction between the juxtamembrane region of the p55 TNF receptor and a
newly discovered 47-kDa isoform of phosphatidylinositol-4-phosphate 5-kinase (PIP5K), a
member of the enzyme family that generates the key signaling messenger …