Faces and phases of human CD8+ T-cell development
D Hamann, MTL Roos, RAW van Lier - Immunology today, 1999 - cell.com
D Hamann, MTL Roos, RAW van Lier
Immunology today, 1999•cell.comAfter viral infection, naive CD8+ T cells become activated and either differentiate into effector
cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re-
challenge with virus. Here, Dörte Hamann and colleagues propose a model for antigen-
induced differentiation of human CD8+ T cells in vivo and discuss its implications for the
lineage relation between memory and effector T cells.
cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re-
challenge with virus. Here, Dörte Hamann and colleagues propose a model for antigen-
induced differentiation of human CD8+ T cells in vivo and discuss its implications for the
lineage relation between memory and effector T cells.
Abstract
After viral infection, naive CD8+ T cells become activated and either differentiate into effector cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re-challenge with virus. Here, Dörte Hamann and colleagues propose a model for antigen-induced differentiation of human CD8+ T cells in vivo and discuss its implications for the lineage relation between memory and effector T cells.
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