MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and …
RM Zinkernagel, PC Doherty - Advances in immunology, 1979 - Elsevier
Publisher Summary This chapter focuses on the important discovery that virus-specific
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by
the major histocompatibility complex (MHC). The initial work was carried out on the
lymphocytic choriomeningitis virus system but it soon became evident that the same
phenomenon applied to many other viruses. In addition, the same principle has been found
to hold for other antigenic systems, such as trinitrophenyl coupled to cells, minor …
cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by
the major histocompatibility complex (MHC). The initial work was carried out on the
lymphocytic choriomeningitis virus system but it soon became evident that the same
phenomenon applied to many other viruses. In addition, the same principle has been found
to hold for other antigenic systems, such as trinitrophenyl coupled to cells, minor …