[HTML][HTML] Differential effects of the integrins α9β1, αvβ3, and αvβ6 on cell proliferative responses to tenascin: roles of the β subunit extracellular and cytoplasmic …
Y Yokosaki, H Monis, J Chen, D Sheppard - Journal of Biological Chemistry, 1996 - ASBMB
Members of the integrin family manifest considerable overlap in ligand specificity, and many
cells have the capacity to express multiple integrin receptors for the same ligand. For
example, at least 5 different integrins recognize tenascin as a ligand, and 4 of these bind to
the same region of the protein, the third fibronectin type III repeat (TNfn3). We utilized colon
carcinoma cells (SW480) that do not normally attach to TNfn3 to examine the possibility that
ligation of different integrin receptors for this ligand would induce different effects on cell …
cells have the capacity to express multiple integrin receptors for the same ligand. For
example, at least 5 different integrins recognize tenascin as a ligand, and 4 of these bind to
the same region of the protein, the third fibronectin type III repeat (TNfn3). We utilized colon
carcinoma cells (SW480) that do not normally attach to TNfn3 to examine the possibility that
ligation of different integrin receptors for this ligand would induce different effects on cell …