[HTML][HTML] Identification of a third pathway for arachidonic acid mobilization and prostaglandin production in activated P388D1 macrophage-like cells
J Balsinde, MA Balboa, EA Dennis - Journal of Biological Chemistry, 2000 - ASBMB
Previous studies have demonstrated that P388D 1 macrophages are able to mobilize
arachidonic acid (AA) and synthesize prostaglandins in two temporally distinct phases. The
first phase is triggered by platelet-activating factor within minutes, but needs the cells to be
previously exposed to bacterial lipopolysaccharide (LPS) for periods up to 1 h. It is thus a
primed immediate phase. The second, delayed phase occurs in response to LPS alone over
long incubation periods spanning several hours. Strikingly, the effector enzymes involved in …
arachidonic acid (AA) and synthesize prostaglandins in two temporally distinct phases. The
first phase is triggered by platelet-activating factor within minutes, but needs the cells to be
previously exposed to bacterial lipopolysaccharide (LPS) for periods up to 1 h. It is thus a
primed immediate phase. The second, delayed phase occurs in response to LPS alone over
long incubation periods spanning several hours. Strikingly, the effector enzymes involved in …