Metabolism of 5 (6) Oxidoeicosatrienoic acid by ram seminal vesicles. Formation of two stereoisomers of 5-hydroxyprostaglandin I1.
EH Oliw - Journal of Biological Chemistry, 1984 - ASBMB
Cytochrome P-450 can metabolize arachidonic (5, 8, 11, 14-eicosatetraenoic) acid to four
epoxides. One of them, cis-5 (6) oxido-8, 11, 14-eicosatrienoic acid, has been reported to
possess biological activity. To ascertain whether this epoxide could be a substrate for the
enzyme fatty acid cyclooxygenase, synthetic 3H-labeled cis-5 (6)-oxido-8, 11, 14-
eicosatrienoic acid was incubated with microsomes of ram seminal vesicles and incubated
with microsomes of ram seminal vesicles and the products were separated by reversed …
epoxides. One of them, cis-5 (6) oxido-8, 11, 14-eicosatrienoic acid, has been reported to
possess biological activity. To ascertain whether this epoxide could be a substrate for the
enzyme fatty acid cyclooxygenase, synthetic 3H-labeled cis-5 (6)-oxido-8, 11, 14-
eicosatrienoic acid was incubated with microsomes of ram seminal vesicles and incubated
with microsomes of ram seminal vesicles and the products were separated by reversed …