The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor
FC Denison, AA Calder, RW Kelly - American journal of obstetrics and …, 1999 - Elsevier
Objective: The objective of this study was to investigate regulation of inflammatory mediators
implicated in cervical ripening and to explore the mechanisms by which the clinically
effective agent prostaglandin E2 may mediate cervical ripening. Study Design: Cervical
biopsy specimens were taken from healthy, nonpregnant women undergoing a
hysterectomy for a benign nonmalignant condition and were cultured, with treatments in
quadruplicate, for 24 hours in media supplemented with progesterone, dexamethasone …
implicated in cervical ripening and to explore the mechanisms by which the clinically
effective agent prostaglandin E2 may mediate cervical ripening. Study Design: Cervical
biopsy specimens were taken from healthy, nonpregnant women undergoing a
hysterectomy for a benign nonmalignant condition and were cultured, with treatments in
quadruplicate, for 24 hours in media supplemented with progesterone, dexamethasone …