Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist
DF Woodward, CE Protzman, AHP Krauss, LS Williams - Prostaglandins, 1993 - Elsevier
The physiological significance of the formation of large quantities of 19 (R)-hydroxy
prostaglandin E's (19-OH PGE) from PGE 1 and PGE 2 in human seminal plasma is
intriguing. The concept that prostaglandins exert their biological effects by interacting with
specific receptors, according to the current working classification for prostanoid receptors,
was employed as a conceptual framework to re-examine the activity of 19 (R)-OH PG's. In
contrast to PGE 2, which may indiscriminately stimulate a variety of prostanoid receptor …
prostaglandin E's (19-OH PGE) from PGE 1 and PGE 2 in human seminal plasma is
intriguing. The concept that prostaglandins exert their biological effects by interacting with
specific receptors, according to the current working classification for prostanoid receptors,
was employed as a conceptual framework to re-examine the activity of 19 (R)-OH PG's. In
contrast to PGE 2, which may indiscriminately stimulate a variety of prostanoid receptor …