Cyclooxygenase-2–specific inhibitors: are they safe?
TJ Schnitzer - The American journal of medicine, 2001 - Elsevier
The basic tenet of the cyclooxygenase-2 (COX-2) hypothesis rests on the fact that sparing of
inhibition of COX-1 should result in greater safety than if both COX isoforms are inhibited.
This increase in safety should be most evident in those organs and tissues in which COX-1
alone has important, necessary physiologic functions (eg, the stomach and platelets). Data
from large clinical trials are now available to support the superior gastrointestinal safety of
COX-2 inhibitors, not only for endoscopic endpoints but also for clinically significant …
inhibition of COX-1 should result in greater safety than if both COX isoforms are inhibited.
This increase in safety should be most evident in those organs and tissues in which COX-1
alone has important, necessary physiologic functions (eg, the stomach and platelets). Data
from large clinical trials are now available to support the superior gastrointestinal safety of
COX-2 inhibitors, not only for endoscopic endpoints but also for clinically significant …