The discovery of an inducible form of prostaglandin synthase initiated a reexamination of the
biochemical pathways for ligand-induced prostaglandin synthesis. As a result, new
pharmaceutical agents with potential activity against pain, fever, chronic and acute
inflammation, cardiovascular disorders, and colon cancer have been developed and are
currently under intense investigation. Careful biochemical and pharmacologic studies of the
differences between the constitutive and inducible prostaglandin synthase enzymes have …