Allergic and autoimmune reactions to xenobiotics: how do they arise?
P Griem, M Wulferink, B Sachs, JB González… - Immunology today, 1998 - cell.com
P Griem, M Wulferink, B Sachs, JB González, E Gleichmann
Immunology today, 1998•cell.comInduction of allergic and autoimmune reactions by drugs and other chemicals constitutes a
major public health problem. Elucidation of the underlying mechanisms might help improve
diagnostic tools and therapeutic approaches. Here, Peter Griem and colleagues focus on
several aspects of neoantigen formation by xenobiotics: metabolism of xenobiotics into
reactive, haptenic metabolites; polymorphisms of metabolizing enzymes; induction of
costimulatory signals; and sensitization of T cells.
major public health problem. Elucidation of the underlying mechanisms might help improve
diagnostic tools and therapeutic approaches. Here, Peter Griem and colleagues focus on
several aspects of neoantigen formation by xenobiotics: metabolism of xenobiotics into
reactive, haptenic metabolites; polymorphisms of metabolizing enzymes; induction of
costimulatory signals; and sensitization of T cells.
Abstract
Induction of allergic and autoimmune reactions by drugs and other chemicals constitutes a major public health problem. Elucidation of the underlying mechanisms might help improve diagnostic tools and therapeutic approaches. Here, Peter Griem and colleagues focus on several aspects of neoantigen formation by xenobiotics: metabolism of xenobiotics into reactive, haptenic metabolites; polymorphisms of metabolizing enzymes; induction of costimulatory signals; and sensitization of T cells.
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