Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions
N Yawalkar, M Shrikhande, Y Hari, H Nievergelt… - Journal of allergy and …, 2000 - Elsevier
Background: Cutaneous drug reactions may be associated with increased numbers of
eosinophils in the blood and tissue. However, the factors leading to the generation of
eosinophilia have not been fully delineated. Objective: The aim of this study was to
investigate the in situ expression of IL-5, eotaxin, RANTES, monocyte chemoattractant
protein 3, and IL-8 together with the appearance of eosinophils in acute cutaneous drug
reactions. Methods: Skin biopsy specimens were obtained from drug-induced …
eosinophils in the blood and tissue. However, the factors leading to the generation of
eosinophilia have not been fully delineated. Objective: The aim of this study was to
investigate the in situ expression of IL-5, eotaxin, RANTES, monocyte chemoattractant
protein 3, and IL-8 together with the appearance of eosinophils in acute cutaneous drug
reactions. Methods: Skin biopsy specimens were obtained from drug-induced …