The molecular biology of glucose transport: relevance to insulin resistance and non-insulin-dependent diabetes mellitus
M Mueckler - Journal of diabetes and its complications, 1993 - Elsevier
The structure of the glucose transporter and the characteristics of the identified members of
the facilitative glucose transporter gene family (GLUT1–5) are reviewed. The role of glucose
transport in insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) is
discussed. The potential contributions of genetic mutation and disruption of short-or long-
term regulation of glucose transporters, particularly GLUT4, in insulin-sensitive tissues to the
etiology of NIDDM are examined.
the facilitative glucose transporter gene family (GLUT1–5) are reviewed. The role of glucose
transport in insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) is
discussed. The potential contributions of genetic mutation and disruption of short-or long-
term regulation of glucose transporters, particularly GLUT4, in insulin-sensitive tissues to the
etiology of NIDDM are examined.