The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.
JS Cox, RE Chapman, P Walter - Molecular biology of the cell, 1997 - Am Soc Cell Biol
JS Cox, RE Chapman, P Walter
Molecular biology of the cell, 1997•Am Soc Cell BiolThe endoplasmic reticulum (ER) is a multifunctional organelle responsible for production of
both lumenal and membrane components of secretory pathway compartments. Secretory
proteins are folded, processed, and sorted in the ER lumen and lipid synthesis occurs on the
ER membrane itself. In the yeast Saccharomyces cerevisiae, synthesis of ER components is
highly regulated: the ER-resident proteins by the unfolded protein response and membrane
lipid synthesis by the inositol response. We demonstrate that these two responses are …
both lumenal and membrane components of secretory pathway compartments. Secretory
proteins are folded, processed, and sorted in the ER lumen and lipid synthesis occurs on the
ER membrane itself. In the yeast Saccharomyces cerevisiae, synthesis of ER components is
highly regulated: the ER-resident proteins by the unfolded protein response and membrane
lipid synthesis by the inositol response. We demonstrate that these two responses are …
The endoplasmic reticulum (ER) is a multifunctional organelle responsible for production of both lumenal and membrane components of secretory pathway compartments. Secretory proteins are folded, processed, and sorted in the ER lumen and lipid synthesis occurs on the ER membrane itself. In the yeast Saccharomyces cerevisiae, synthesis of ER components is highly regulated: the ER-resident proteins by the unfolded protein response and membrane lipid synthesis by the inositol response. We demonstrate that these two responses are intimately linked, forming different branches of the same pathway. Furthermore, we present evidence indicating that this coordinate regulation plays a role in ER biogenesis.
Am Soc Cell Biol