Osteoprotegerin ligand: a regulator of immune responses and bone physiology
YY Kong, WJ Boyle, JM Penninger - Immunology today, 2000 - cell.com
YY Kong, WJ Boyle, JM Penninger
Immunology today, 2000•cell.comThe TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL
and ODF) is a key regulator of bone remodeling and essential for the development and
activation of osteoclasts. Intriguingly, OPGL also regulates T cell–dendritic cell
communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun
Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune
system and in bone metabolism.
and ODF) is a key regulator of bone remodeling and essential for the development and
activation of osteoclasts. Intriguingly, OPGL also regulates T cell–dendritic cell
communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun
Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune
system and in bone metabolism.
Abstract
The TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell–dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.
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