[HTML][HTML] Outside-in Integrin Signal Transduction: αIIbβ3-(GP IIb-IIIa) TYROSINE PHOSPHORYLATION INDUCED BY PLATELET AGGREGATION (∗)
DA Law, L Nannizzi-Alaimo, DR Phillips - Journal of Biological Chemistry, 1996 - ASBMB
α IIb β 3-(GPIIb-IIIa) is the most abundant integrin expressed on platelets and plays a critical
role in platelet aggregation and normal hemostasis. In response to platelet stimulation by
agonists such as thrombin, α IIb β 3 becomes a receptor for the adhesive proteins fibrinogen,
von Willebrand factor, vitronectin, and fibronectin. Binding of extracellular matrix ligands
allows the integrin to transmit a signal to the inside of the cell, but the exact mechanisms
whereby integrins transduce these signals remain unclear. In this paper we demonstrate that …
role in platelet aggregation and normal hemostasis. In response to platelet stimulation by
agonists such as thrombin, α IIb β 3 becomes a receptor for the adhesive proteins fibrinogen,
von Willebrand factor, vitronectin, and fibronectin. Binding of extracellular matrix ligands
allows the integrin to transmit a signal to the inside of the cell, but the exact mechanisms
whereby integrins transduce these signals remain unclear. In this paper we demonstrate that …