Immortalization of neuroendocrine cells by targeted oncogenesis

PL MELLON, JJ WINDLE, RI WEINER - Proceedings of the 1990 Laurentian …, 1991 - Elsevier
Publisher Summary This chapter discusses the immortalization of neuroendocrine cells by
targeted oncogenesis. By targeting Tag expression to the early developing anterior pituitary
with the α-subunit promoter, a developmental precursor of the mature gonadotrope has
been immortalized. Although this approach has proved difficult in the neural cells of the
brain, targeting with a gene that is very tightly expressed in a small population of neurons
prior to the transition to the postmitotic state may be successful. Specific tumors of …