Tumor-associated macrophages press the angiogenic switch in breast cancer
EY Lin, JW Pollard - Cancer research, 2007 - AACR
EY Lin, JW Pollard
Cancer research, 2007•AACRThe development of a supportive vasculature is essential for tumor progression. In a mouse
model of breast cancer, we found that tumor-associated macrophages that are recruited to
the tumor just before malignant conversion are essential for the angiogenic switch. These
findings establish a causal linkage to explain well-documented clinical correlations between
macrophages, microvessel density, and poor prognosis in breast tumors.[Cancer Res 2007;
67 (11): 5064–3]
model of breast cancer, we found that tumor-associated macrophages that are recruited to
the tumor just before malignant conversion are essential for the angiogenic switch. These
findings establish a causal linkage to explain well-documented clinical correlations between
macrophages, microvessel density, and poor prognosis in breast tumors.[Cancer Res 2007;
67 (11): 5064–3]
Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors. [Cancer Res 2007;67(11):5064–3]
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