Specific immunosuppression of corneal allograft rejection by combination of anti-VLA-4 and anti-LFA-1 monoclonal antibodies in mice
J HORI, M ISOBE, S YAMAGAMI, T MIZUOCHI… - Experimental eye …, 1997 - Elsevier
It has been reported that allograft rejection is mediated by a variety of adhesion molecules.
Using a corneal allograft model in mice, we studied the role of very late antigen (VLA)-4 and
leukocyte function-associated antigen (LFA)-1 adhesion molecules in corneal allograft
rejection and the effects of monoclonal antibodies (mAbs) to them in suppressing corneal
rejection. C3H/He donor corneas were transplanted into BALB/c corneal beds. The
allografted mice were treated with a control mAb (M18/2), mAbs to VLA-4, or LFA-1 or their …
Using a corneal allograft model in mice, we studied the role of very late antigen (VLA)-4 and
leukocyte function-associated antigen (LFA)-1 adhesion molecules in corneal allograft
rejection and the effects of monoclonal antibodies (mAbs) to them in suppressing corneal
rejection. C3H/He donor corneas were transplanted into BALB/c corneal beds. The
allografted mice were treated with a control mAb (M18/2), mAbs to VLA-4, or LFA-1 or their …
