Integrins are a major family of cell-matrix and cell-cell receptors. Bidirectional signal
transmission between the extracellular matrix or other integrin ligands and the
submembranous cytoskeleton and associated adaptor proteins is now being resolved (1–6).
This review will concentrate on an emerging area of study: how the type of adhesion and the
signaling following integrin ligation may be modulated by lateral interactions with other
membrane components. This may occur through direct or indirect interactions. Two major …