[HTML][HTML] Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane
CE Gargiulo, SM Stuhlsatz-Krouper, JE Schaffer - Journal of lipid research, 1999 - ASBMB
Long-chain fatty acyl-CoA synthetase (FACS) catalyzes esterification of long-chain fatty
acids (LCFAs) with coenzyme A (CoA), the first step in fatty acid metabolism. FACS has been
shown to play a role in LCFA import into bacteria and implicated to function in mammalian
cell LCFA import. In the present study, we demonstrate that FACS overexpression in
fibroblasts increases LCFA uptake, and overexpression of both FACS and the fatty acid
transport protein (FATP) have synergistic effects on LCFA uptake. To explore how FACS …
acids (LCFAs) with coenzyme A (CoA), the first step in fatty acid metabolism. FACS has been
shown to play a role in LCFA import into bacteria and implicated to function in mammalian
cell LCFA import. In the present study, we demonstrate that FACS overexpression in
fibroblasts increases LCFA uptake, and overexpression of both FACS and the fatty acid
transport protein (FATP) have synergistic effects on LCFA uptake. To explore how FACS …