Bidirectional signaling between the cytoskeleton and integrins
SM Schoenwaelder, K Burridge - Current opinion in cell biology, 1999 - Elsevier
Current opinion in cell biology, 1999•Elsevier
Clustering of integrins into focal adhesions and focal complexes is regulated by the actin
cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-
mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia
and stress fibers. In the past few years, signaling pathways have begun to be identified that
promote focal adhesion disassembly and integrin dispersal. Many of these pathways result
in decreased myosin-mediated cell contractility.
cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-
mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia
and stress fibers. In the past few years, signaling pathways have begun to be identified that
promote focal adhesion disassembly and integrin dispersal. Many of these pathways result
in decreased myosin-mediated cell contractility.
Clustering of integrins into focal adhesions and focal complexes is regulated by the actin cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia and stress fibers. In the past few years, signaling pathways have begun to be identified that promote focal adhesion disassembly and integrin dispersal. Many of these pathways result in decreased myosin-mediated cell contractility.
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