[HTML][HTML] Induction of Acute Translational Response Genes by Homocysteine: ELONGATION FACTORS-1α,-β, AND-δ
G Chacko, Q Ling, KA Hajjar - Journal of Biological Chemistry, 1998 - ASBMB
The thiol amino acid homocysteine (HC) accumulates in homocystinuria and homocyst (e)
inemia, and is associated with a wide variety of clinical manifestations. To determine
whether HC influences the cell's program of gene expression, vascular endothelial cells
were treated with HC for 6–42 h and analyzed by differential display. We found a 3–7-fold,
time-dependent induction of a 220-base pair fragment, which demonstrated complete
sequence identity with elongation factor-1δ (EF-1δ), a member of the multimeric complex …
inemia, and is associated with a wide variety of clinical manifestations. To determine
whether HC influences the cell's program of gene expression, vascular endothelial cells
were treated with HC for 6–42 h and analyzed by differential display. We found a 3–7-fold,
time-dependent induction of a 220-base pair fragment, which demonstrated complete
sequence identity with elongation factor-1δ (EF-1δ), a member of the multimeric complex …