[HTML][HTML] Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vaca types with cytotoxin production and peptic ulceration (∗)
JC Atherton, P Cao, RM Peek, MKR Tummuru… - Journal of Biological …, 1995 - ASBMB
Approximately 50% of Helicobacter pylori strains produce a cytotoxin, encoded by vacA, that
induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox-strain (Tx30a)
indicated secretion of a 93-kDa product from a 3933-base pair vacA open reading frame.
Characterization of 59 different H. pylori isolates indicated the existence of three different
families of vacA signal sequences (s1a, s1b, and s2) and two different families of middle-
region alleles (m1 and m2). All possible combinations of these vacA regions were identified …
induces vacuolation of eukaryotic cells. Analysis of a clinically isolated tox-strain (Tx30a)
indicated secretion of a 93-kDa product from a 3933-base pair vacA open reading frame.
Characterization of 59 different H. pylori isolates indicated the existence of three different
families of vacA signal sequences (s1a, s1b, and s2) and two different families of middle-
region alleles (m1 and m2). All possible combinations of these vacA regions were identified …